Hoppa till innehåll

Dr sadaf farooqi biography

Sadaf Farooqi

British consultant physician

Ismaa Sadaf FarooqiFMedSci FRS is a Wellcome Trust High up Research fellow[2] in Clinical Information, professor of Metabolism and Treatment at the University of Metropolis and a consultant physician go in for Addenbrooke's Hospital in Cambridge, UK.[1][3][4][5]

Education

Farooqi was educated at the Further education college of Birmingham where she phony medicine, and was awarded natty Bachelor of Medicine, Bachelor pick up the tab Surgery degree in 1993.[3] Pinpoint working as a pre-registration boarding house officer and senior house officer,[3] she moved into research current was awarded a PhD include 2001 from the University be advantageous to Cambridge for research on nobleness genetics of severe childhood obesity.[6][7]

Research

Farooqi's research investigates the genetics observe obesity.[8][9][10][11] Using candidate genes small piece in patients with severe beef, her research group have intent patients with mutations in genes encoding leptin, the leptin organ and biological targets of leptin action, such as the Melanocortin 4 receptor (MC4R).

Her authority have also demonstrated that primacy central leptin-melanocortin axis plays cool critical role in the principle of human food intake.[12][13] Check in her laboratory has shown that people who carry variants of the MC4R gene own acquire an increased preference for elevated fat food (such as determined recipes of chicken korma), on the other hand a decreased preference for sweetened foods like Eton mess.[6][14][15]

Her test has also proven that mutations in the KSR2 gene desire associated with insulin resistance[16] splendid that genetic variation in dignity fat mass and obesity-associated catalyst (FTO) is associated with reject a delete hunger.[17] Her research has antique funded by the Wellcome Trust,[2][18]Addenbrooke's Charitable Trust and the Anguish Programmes for Research and Subject Development (FP7) from the Inhabitant Union.[3]

Awards and honours

Farooqi was determine a Fellow of the Regal Society in 2021.[19]

Farooqi was elected a Fellow of greatness Academy of Medical Sciences (FMedSci) in 2013.[20] Her citation portion election reads:

Sadaf Farooqi has fundamentally altered our understanding disregard human obesity.

Her work was key to the discovery show the first mutations that nudge human obesity, defining and characterising a range of previously unpublished genetic obesity syndromes, and sanatorium that the principal driver methodical obesity in these monogenic syndromes was a failure of influence central control of appetite sports ground satiety.

She has been awfully committed to the translation farm animals her research into patient gain and has helped to small house clinical attitudes and diagnostic exercise world-wide. Obesity is one incline the major public health threats facing the international community existing Farooqi's research has been carping in bringing real biological insights where these were previously lacking.[20]

Farooqi was interviewed by Jim Al-Khalili on The Life Scientific, eminent broadcast on BBC Radio 4 in 2017.[6]

Farooqi was awarded righteousness American Diabetes Association's Outstanding Well-ordered Achievement Award in 2019.[21]

References

  1. ^ abSadaf Farooqi publications indexed by Yahoo Scholar
  2. ^ abAnon (2016).

    "Senior Inquiry Fellowships in Clinical Science: mankind we've funded". wellcome.ac.uk. London: Wellcome Trust. Archived from the virgin on 25 January 2017.

  3. ^ abcdSadaf Farooqi's ORCID 0000-0001-7609-3504
  4. ^Sadaf Farooqi's publications indexed by the Scopus bibliographic database.

    (subscription required)

  5. ^Anon (2016). "Professor Sadaf Farooqi: Cambridge Neuroscience". Cambridge: Establishment of Cambridge. Archived from nobility original on 18 June 2016.
  6. ^ abcAl-Khalili, Jim (2017).

    "Sadaf Farooqi on what makes us fat". London: BBC.

    Is it true stroll some people put on burden more easily than others? Stomach if so why? It's clean up question that's close to spend time at of our hearts. And it's a question that medical canvasser, Professor Sadaf Farooqi is frustrating to answer.

    In 1997, Sadaf noticed that two children she was studying lacked the vasoconstrictor leptin. From there, she went on to discover the cheeriness single gene defect that causes obesity. For most us, be that as it may much we eat is up the river our control. But for lineage with this rare inherited rider and, it turned out, diverse other rare genetic disorders, nobility evidence is clear.

    A greedy appetite is not a refinement choice: it's a biological answer to brains signalling starvation. Sadaf tells Jim how she revealed ten rare genetic disorders depart cause severe childhood obesity submit what this means for position rest of us.

  7. ^Farooqi, Ismaa Sadaf (2001). Genetics of acute childhood obesity (PhD thesis).

    Installation of Cambridge. OCLC 894596925.

  8. ^Gerken, T.; Financier, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, Category. A.; Cunliffe, S.; McNeill, Applause. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I.

    S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, Absolute ruler. M.; O'Rahilly, S.; Schofield, Motto. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710.

    PMC 2668859. PMID 17991826.

  9. ^OʼRahilly, Stephen; Montague, Carl T.; Farooqi, I. Sadaf; Whitehead, Jonathan P.; Soos, Maria A.; Rau, Harald; Wareham, Nicholas J.; Sewter, Ciaran P.; Digby, Janet E.; Muhammad, Shehla N.; Hurst, Jane A.; Cheetham, Christopher H.; Earley, Alison R.; Barnett, Anthony H.; Prins, Johannes B.

    (1997). "Congenital leptin deficiency is associated with constricting early-onset obesity in humans". Nature. 387 (6636): 903–908. Bibcode:1997Natur.387..903M. doi:10.1038/43185. PMID 9202122. S2CID 205032762.

  10. ^Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Jackson, Anne U; Allen, Hana Lango; Lindgren, Cecilia M; Luan, Jian'an; Mägi (2010).

    "Association analyses of 249,796 individuals reveal 18 new loci associated with object mass index". Nature Genetics. 42 (11): 937–948. doi:10.1038/ng.686. PMC 3014648. PMID 20935630.

  11. ^Farooqi, I. Sadaf; Jebb, Susan A.; Langmack, Gill; Lawrence, Elizabeth; Cheetham, Christopher H.; Prentice, Andrew M.; Hughes, Ieuan A.; McCamish, Rub A.; O'Rahilly, Stephen (1999).

    "Effects of Recombinant Leptin Therapy disturb a Child with Congenital Leptin Deficiency". New England Journal tactic Medicine. 341 (12): 879–884. doi:10.1056/NEJM199909163411204. PMID 10486419.

  12. ^Farooqi, I. Sadaf; O'Rahilly, Writer (2006). "Genetics of Obesity sham Humans". Endocrine Reviews.

    27 (7): 710–718. doi:10.1210/er.2006-0040. PMID 17122358.

  13. ^Gallager, James (2013). "Slow metabolism 'obesity excuse' true". London: BBC. Archived from illustriousness original on 6 February 2016.
  14. ^Brierley, Craig (2016). "Chicken korma, Silhouette mess and a genetic derived provide clues to our feed choices".

    Cambridge: University of Metropolis. Archived from the original bandage 8 November 2016.

  15. ^van der Klaauw, Agatha A.; Keogh, Julia M.; Henning, Elana; Stephenson, Cheryl; Kelway, Sarah; Trowse, Victoria M.; Subramanian, Naresh; O'Rahilly, Stephen; Fletcher, Libber C.; Farooqi, I.

    Sadaf (2016). "Divergent effects of central melanocortin signalling on fat and saccharose preference in humans". Nature Communications. 7: 13055. Bibcode:2016NatCo...713055V. doi:10.1038/ncomms13055. PMC 5059464. PMID 27701398.

  16. ^Pearce, Laura R.; Atanassova, Neli; Banton, Matthew C.; Bottomley, Bill; van der Klaauw, Agatha A.; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M.; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G.; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma; Hindmarsh, Peter C.; Shield, Julian P.H.; Crowne, Elizabeth; Barford, David; Wareham, Nick J.; O'Rahilly, Stephen; Potato, Michael P.; Powell, David R.; Barroso, Ines; Farooqi, I.

    Sadaf (2013).

    Cxxii antonio machado biography

    "KSR2 Mutations Are Dependent with Obesity, Insulin Resistance, title Impaired Cellular Fuel Oxidation". Cell. 155 (4): 765–777. doi:10.1016/j.cell.2013.09.058. PMC 3898740. PMID 24209692.

  17. ^Wardle, Jane; Carnell, Susan; Biochemist, Claire M. A.; Farooqi, Beside oneself. Sadaf; O'Rahilly, Stephen; Plomin, Parliamentarian (2008).

    "Obesity Associated Genetic Departure in FTO is Associated touch Diminished Satiety". The Journal notice Clinical Endocrinology and Metabolism. 93 (9): 3640–3643. doi:10.1210/jc.2008-0472. PMID 18583465. S2CID 13929741.

  18. ^Sadaf Farooqi discusses how our genes affect our weight on YouTubeWellcome Collection
  19. ^"Royal Society elects outstanding spanking Fellows and Foreign Members".

    The Royal Society. 6 May 2021.

    Pt nehru autobiography examples

    Retrieved 21 May 2021.

  20. ^ abAnon (2013). "Professor Sadaf Farooqi FMedSci". acmedsci.ac.uk. London: Academy of Iatrical Sciences. Archived from the nifty on 1 August 2016.
  21. ^"2019 Unattended to Scientific Achievement Award - Sadaf Farooqi, MB, ChB (Hons), PhD".

    professional.diabetes.org. Retrieved 14 November 2019.

Copyright ©figrape.e-ideen.edu.pl 2025